Skip to main navigation menu Skip to main content Skip to site footer

PERAN FITOTERAPI SEBAGAI AGEN IMUNOMODULATOR DALAM MENINGKATKAN SISTEM IMUN TUBUH: TINJAUAN LITERATUR

Abstract

This study aims to review the potential of herbal plants as immunomodulatory agents using a literature review method. The analysis was conducted by examining national and international scientific articles related to the immune system and the use of herbal plants. Data sources were obtained from Google Scholar and PubMed databases, with publications ranging from 2020 to 2025. Articles that met the inclusion criteria were analyzed descriptively and critically to identify types of herbal plants, immunomodulatory mechanisms, and community-based utilization approaches. The findings indicate that various herbal plants can modulate the immune system through immune cell stimulation, inflammation reduction, gut microbiota modulation, and enhancement of adaptive immune responses. In addition, the utilization of herbal plants is influenced by educational factors, cultural acceptance, and technological innovation. This study concludes that herbal plants have strong potential as supportive immunomodulators when applied rationally and based on scientific evidence.

Keywords

Herbal Plants, Immunomodulator, Immune System, Literature Review

pdf

References

  1. Ayustaningwarno, F., Anjani, G., Ayu, A. M., & Fogliano, V. (2024). A Critical Review Of Ginger’s (Zingiber Officinale) Antioxidant, Anti-Inflammatory, And Immunomodulatory Activities. Frontiers In Nutrition, 11, 1364836.
  2. Cingi, C., Muluk, N. B., Tezol, A., & Çukurova, I. (2023). Efficacy Of Traditional Herbal Formulas On Human Immunity. European Review For Medical & Pharmacological Sciences, 27.
  3. Dewi, D. C., Rozi, V. F., Novitasari, D., Novega, N., Fitriza, M. K., & Miranda, T. G. (2024). Sosialisasi Dan Edukasi Tentang Peran Jamu Dalam Meningkatkan Sistem Imunitas Tubuh Dalam Menghadapi Musim Pancaroba Di Desa Srikuncoro Bengkulu Tengah. Jurnal Pengabdian Masyarakat (Jupemas), 5(1).
  4. Haris, M., Fauzi, A., & Khair, H. (2024). Pemilihan Tanaman Herbal Untuk Meningkatkan Imun Tubuh Manusia Menggunakan Metode Weighted Product. Indonesian Journal Of Science, Technology And Humanities, 1(3), 139–147.
  5. Hartono, M., & Penyami, Y. (2025). Uji Efektifitas Suplementasi Minyak Zaitun Extra Virgin Dengan Extrac Bawang Putih Terhadap Tekanan Darah Dan Imunitas Tubuh Pasien Hypertensi Yang Beresiko Sebagai Comorbid Infeksi Covid-19 Di Kota Pekalongan. Jurnal Lintas Keperawatan, 6(2), 486-500.
  6. Hidayati, E. N., Santoso, J., & Ma’rifah, B. (2023). Edukasi Pemanfaatan Tanaman Herbal Untuk Peningkatan Sistem Imun Di Kelurahan Mojosongo Surakarta. Jpemas: Jurnal Pengabdian Kepada Masyarakat, 1(2), 140-143.
  7. Hooda, P., Malik, R., Bhatia, S., Al-Harrasi, A., Najmi, A., Zoghebi, K., ... & Mohan, S. (2024). Phytoimmunomodulators: A Review Of Natural Modulators For Complex Immune System. Heliyon, 10(1).
  8. Jiwantoro, Y. A., & Pauzi, I. (2023). Pemberdayaan Masyarakat Dalam Meningkatkan Kekebalan Tubuh Melalui Olahan Rempah-Rempah Di Kelurahan Dasan Cerman: Empowerment Community In Increasing Immunity Through Processing Of Herbs And Spices In Kelurahan Dasan Cermen. Gemakes: Jurnal Pengabdian Kepada Masyarakat, 3(1), 97-102.
  9. Kotala, S., & Kurnia, T. S. (2022). Eksplorasi Tumbuhan Obat Berpotensi Imunomodulator Di Kecamatan Leihitu Kabupaten Maluku Tengah. Sainmatika: Jurnal Ilmiah Matematika Dan Ilmu Pengetahuan Alam, 19(2), 186-200.
  10. Milad, S. S., Elshoky, H. A., Ali, S. E., Khattab, M. S., Attia, M. Z., & Azouz, A. M. (2025). Nanoparticle Delivery Of Combined Plant Extracts Enhances Immune Response In Immunocompromised Rats. Scientific Reports, 15(1), 39015.
  11. Min, S. J., Kim, S. J., Park, J. Y., Seo, C. S., & Choi, Y. K. (2023). Preparation Of Herbal Extracts For Intestinal Immune Modulation Activity Based On In Vitro Screening And In Vivo Evaluation Of Zingiber Officinale Rosc. Extracts. Molecules, 28(18), 6743.
  12. Ningsih, A. W. (2021). Penyuluhan Pemanfaatan Tanaman Obat Peningkat Sistem Imun Untuk Pencegahan Dan Penanggulangan Penyakit Covid-19 Di Masyarakat. Jurnal Pengabdian Masyarakat Mipa Dan Pendidikan Mipa, 5(1), 53–57. Https://Doi.Org/10.21831/Jpmmp.V5i1.34366
  13. Perdana, P. G. R. W. (2021). Review Artikel: Aktivitas Imunomodulator Ekstrak Herba Meniran (Phyllanthus Niruri L.). Jurnal Farmasi Malahayati, 4(1), 44-52.
  14. Rifqi, M., Kurniawati, D., & Syamsu, E. (2023). Hubungan Pengetahuan Terhadap Pemanfaatan Obat Herbal Imunomodulator Di Rt 24 Kelayan B. Jurnal Farmasi Syifa, 1(2), 48-53.
  15. Rohmatulkhasanah, F. A. (2025). Potensi Imunomodulator Tanaman Echinacea Purpurea Pada Sistem Imun: Studi Literatur. Jurnal Gizi Ilmiah, 12(1), 47-60.
  16. Suwanto, S., Ernawati, E., Yusa, A., Faria, N., Shofi, A. T., & Purbasari, S. (2022). Pemanfaatan Fitoterapi Sebagai Imunomodulator Pada Masa Pandemi Covid-19 Di Kelurahan Sukodono Kabupaten Gresik. Duta Abdimas, 1(2), 12-Â.
  17. Wardana, M. F. (2022). Preferensi Masyarakat Dalam Mengonsumsi Produk Rempah (Jamu) Untuk Meningkatkan Imun Tubuh Pasca Pandemi.
  18. Walid, M., Endriyanto, N. C., Susanti, N., Astuti, W. M., & Trihawa, I. (2023). Herbal Medicine Untuk Peningkatan Imunitas Dalam Menghadapi Musim Pancaroba. Journal Of Health Innovation And Community Service, 2(1), 8–14.
  19. Yanuarty, R., Toding, F. A., & Nurhaliza, S. (2024). Edukasi Pemanfaatan Jahe Untuk Meningkatkan Sistem Imun Tubuh Di Desa Powelua, Kabupaten Donggala, Sulawesi Tengah. Jurnal Mandala Pengabdian Masyarakat, 5(2), 223-228.
  20. Yuliana, A., Noviana, N. W., Lestari, T., & Rahmawati, L. (2021). Potensi Immunomodulator Tanaman Herbal Tradisional Indonesia Terhadap Sars-Cov-2. In Prosiding Seminar Nasional Diseminasi Hasil Penelitian Program Studi S1 Farmasi (Vol. 1, No. 1).
  21. Zahiruddin, S., Parveen, A., Khan, W., Ibrahim, M., Want, M. Y., Parveen, R., & Ahmad, S. (2022). Metabolomic Profiling And Immunomodulatory Activity Of A Polyherbal Combination In Cyclophosphamide-Induced Immunosuppressed Mice. Frontiers In Pharmacology, 12, 647244.

Most read articles by the same author(s)

Similar Articles

11-20 of 79

You may also start an advanced similarity search for this article.