Vol. 21 No. 4 (2025)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

LITERATURE REVIEW : PERAN FITOTERAPI ANTIOKSIDAN BERBASIS TANAMAN OBAT DALAM MENANGKAL STRES OKSIDATIF

Published 2026-01-17

  • Nawwar Irfan
    • ,
  • Adinda Salsabila
    • ,
  • Aulia Khairunnisa
    • ,
  • Tri Linda Wati
    • ,
  • Marisa Kemala Rozi
    • ,
  • Sefrina Putri

Nawwar Irfan
Universitas Muhammadiyah Riau

Adinda Salsabila
Universitas Muhammadiyah Riau

Aulia Khairunnisa
Universitas Muhammadiyah Riau

Tri Linda Wati
Universitas Muhammadiyah Riau

Marisa Kemala Rozi
Universitas Muhammadiyah Riau

Sefrina Putri
Universitas Muhammadiyah Riau

Abstract

Oxidative stress is an imbalance between free radical production and the body’s antioxidant defense system and plays a key role in the development of chronic and degenerative diseases. Phytotherapy based on medicinal plants offers a promising approach to prevent oxidative stress due to its natural antioxidant compounds. This literature review aims to examine plant sources, active compounds, and mechanisms of action of antioxidant phytotherapy. Articles were retrieved from Google Scholar, PubMed, ScienceDirect, and SpringerLink databases published between 2020 and 2025 and selected based on predefined criteria, resulting in 20 relevant studies. The findings indicate that medicinal plants contain phytochemicals such as flavonoids, polyphenols, terpenoids, alkaloids, vitamins, and carotenoids, which exert antioxidant effects by scavenging free radicals, inhibiting lipid peroxidation, and enhancing endogenous antioxidant systems through pathways such as Nrf2/ARE and SIRT1. In conclusion, antioxidant phytotherapy shows strong potential for preventing oxidative stress and may be developed as a natural-based adjunctive therapy.

Keywords

Phytotherapy, Antioxidants, Medicinal Plants, Oxidative Stress

pdf

References

  1. Al-Mijalli, S. H., Al-Malki, A. L., Refaat, H., & Mohamed, D. A. (2022). Chemical composition, antioxidant, anti-diabetic, anti-inflammatory, and antimicrobial properties of Arbutus unedo L. and Laurus nobilis L. essential oils. Molecules, 27(21), 1–20.
  2. Aldo, S., Rahayu, I. D., Ulandari, A. S., & Iqbal, M. (2025). Analisis bibliometrik aktivitas antioksidan ekstrak pare (Momordica charantia L.) sebagai pengobatan tradisional. Sains Medisina, 4(2), 125–132.
  3. Duletić-Laušević, S., Aradski, A. A., Šavikin, K., Zdunić, G., Janković, T., & Menković, N. (2019). In vitro evaluation of antioxidant, antineurodegenerative and antidiabetic activities of Ocimum basilicum L., Laurus nobilis L. leaves and Citrus reticulata Blanco peel extracts. Industrial Crops and Products, 137, 1–10.
  4. Hidayah, N., Fitriani, D., & Rahmawati, S. (2023). Hubungan antara aktivitas antioksidan dan antikanker. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 10(2), 85–94.
  5. Huang, J., Li, Y., Chen, J., & Zhang, L. (2022). Application of natural antioxidants from traditional Chinese medicine in the treatment of spinal cord injury. Frontiers in Pharmacology, 13, 1–18.
  6. Ibroham, S., Wahyuni, S., & Fitriyani, N. (2022). Potensi tumbuhan Indonesia sebagai sumber antioksidan alami: Suatu tinjauan pustaka. Jurnal Farmasi Indonesia, 19(3), 201–213.
  7. Ismail, N. A., Hassan, M. A., & El-Gendy, A. A. (2025). Oxidative stress and antioxidant status in women with polycystic ovary syndrome (PCOS). Journal of Ovarian Research, 18(1), 1–12.
  8. Januarsih, D. (2025). Potensi terapeutik Punica granatum sebagai antioksidan alami pada stres oksidatif. Jurnal Fitofarmaka Indonesia, 12(1), 45–55.
  9. Juliastuti, R., Handayani, D., & Putra, A. E. (2024). Penyuluhan antioksidan dari tumbuhan untuk kesehatan pada masyarakat Kampung Adat Cireundeu Kota Cimahi. Jurnal Pengabdian Kefarmasian, 6(2), 101–108.
  10. Komang, D. M., Saeful, A., & Maharani, K. D. (2025). Aktivitas antioksidan tumbuhan lokal sebagai agen neuroprotektif untuk terapi Alzheimer. Indonesian Journal of Science, 1(6), 1369–1375.
  11. Luo, Y., Wang, X., Chen, Y., & Li, H. (2024). Molecular mechanisms of plant extracts in protecting aging blood vessels. Oxidative Medicine and Cellular Longevity, 2024, 1–15.
  12. Najib, A., & Jannah, R. (2020). Pharmacological activities of Nasturtium officinale. Journal of Herbmed Pharmacology, 9(4), 345–352.
  13. Puspita, R., Wahyuni, F., & Handayani, S. (2024). Implementasi pemanfaatan buah-buahan lokal tinggi kalium dan antioksidan sebagai upaya pengendalian penyakit tidak menular hipertensi di Desa Wonojati. Pekat, 3(1), 41–48.
  14. Rady, A., et al. (2018). Bioactive compounds and antioxidant activity of green tea (Camellia sinensis). Journal of Food Science, 83(7), 1802–1810.
  15. Rozirwan, et al. (2024). Investigating the antioxidant activity, total phenolics and phytochemical profile in Avicennia alba and Excoecaria agallocha root extracts. Sains Medisina, 4(2), 127–131.
  16. Skrovankova, S., & Mlcek, J. (2025). Antioxidant potential and its changes caused by various factors in lesser-known medicinal and aromatic plants. Antioxidants, 14(3), 1–15.
  17. Sari, et al. (2021). Aktivitas antioksidan ekstrak tanaman obat sebagai upaya pencegahan stres oksidatif. Jurnal Fitofarmaka, 10(2), 101–110.
  18. Thana Lakshme, et al. (2021). Exploration of antioxidant effects of crude extract of mangrove plant – Avicennia marina. International Journal of Pharmacognosy, 8(4), 55–63.
  19. Thuwaini, A. (2024). Medicinal plants with antioxidant activity: A review. Jurnal Fitoterapi, 15(1), 11–25.
  20. Zhang, et al. (2025). Plant-derived antioxidants: Molecular mechanisms and therapeutic implications. Journal of Natural Products, 88(5), 1025–1038.
  21. Putri, et al. (2023). Peran senyawa fitokimia tanaman obat sebagai antioksidan alami. Jurnal Farmasi Indonesia, 20(2), 201–212.
  22. Negreanu-Pirjol, T., Negreanu-Pirjol, B., & Istudor, V. (2024). The role of antioxidant plant extracts’ composition and encapsulation in dietary supplements and gemmo-derivatives. Plants, 13(3), 1–22.
  23. Pacifico, S., Piccolella, S., Papale, F., Nocera, P., Lettieri, A., & Catauro, M. (2014). Neuroprotective potential of Laurus nobilis antioxidant polyphenol-enriched leaf extracts. Food Chemistry, 140, 727–735.
  24. Putri, A. D., Lestari, S., & Rahman, F. (2023). Peran senyawa fitokimia tanaman obat sebagai antioksidan alami. Jurnal Ilmu Kefarmasian Indonesia, 21(1), 33–42.
  25. Rady, H. M., Abd El-Kader, E. M., & Mahmoud, A. M. (2018). Bioactive compounds and antioxidant activity of green tea (Camellia sinensis). Journal of Food Biochemistry, 42(5), e12545.
  26. Rozirwan, R., Pratama, M. A., & Lestari, F. (2024). Investigating the antioxidant activity, total phenolics and phytochemical profile in Avicennia alba and Excoecaria agallocha root extracts. Journal of Applied Pharmaceutical Science, 14(1), 112–120.
  27. Sari, R. P., Handayani, D., & Putra, A. E. (2021). Aktivitas antioksidan ekstrak tanaman obat sebagai upaya pencegahan stres oksidatif. Jurnal Farmasi Klinik Indonesia, 10(2), 89–97.
  28. Skrovankova, S., & Mlcek, J. (2025). Antioxidant potential and its changes caused by various factors in lesser-known medicinal and aromatic plants. Antioxidants, 14(2), 1–20.
  29. Thana Lakshme, K., Rajendran, K., & Ramesh, S. (2021). Exploration of antioxidant effects of crude extract of mangrove plant – Avicennia marina. Journal of Applied Pharmaceutical Science, 11(6), 92–98.
  30. Thuwaini, M. M. (2024). Medicinal plants with antioxidant activity: A review.
  31. International Journal of Phytomedicine, 16(1), 1–15.
  32. Zhang, Y., Liu, X., Wang, J., & Chen, Z. (2025). Plant-derived antioxidants: Molecular mechanisms and therapeutic implications. Phytomedicine, 130, 1–14.

Most read articles by the same author(s)

Similar Articles

21-25 of 25

You may also start an advanced similarity search for this article.