Vol. 22 No. 1 (2026)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

LITERATURE REVIEW: AKTIVITAS ANTIKANKER BAHAN ALAM BERBASIS DATA SITOTOKSISITAS, TOKSISITAS, DAN MOLECULAR DOCKING

Published 2026-01-19

  • Nawwar Irfan
    • ,
  • Husnatul Fadillah Pratiwi
    • ,
  • Maidina Putri Rahmadani
    • ,
  • Abdi Nauli Abadi
    • ,
  • Surya Deva

Nawwar Irfan
Program Studi Farmasi, Fakultas MIPA-Kes, Universitas Muhammadiyah Riau

Husnatul Fadillah Pratiwi
Program Studi Farmasi, Fakultas MIPA-Kes, Universitas Muhammadiyah Riau

Maidina Putri Rahmadani
Program Studi Farmasi, Fakultas MIPA-Kes, Universitas Muhammadiyah Riau

Abdi Nauli Abadi
Program Studi Farmasi, Fakultas MIPA-Kes, Universitas Muhammadiyah Riau

Surya Deva
Program Studi Farmasi, Fakultas MIPA-Kes, Universitas Muhammadiyah Riau

Abstract

Cancer is characterized by uncontrolled cell proliferation, requiring effective and selective therapies. This study reviewed the anticancer potential of natural products based on 20 scientific articles. A literature review method was applied by extracting test models and key findings (IC₅₀/LC₅₀, molecular mechanisms, and in silico outputs). The results indicate multi-target activities, including antiproliferative effects and apoptosis induction via p53/Bax/caspase pathways and Bcl-2 downregulation. Strong quantitative evidence was found for soursop leaf extract against MCF-7 cells with an IC₅₀ of 45–55 µg/mL and viability reduced to 18.9% (100 µg/mL; 48 h). A three-plant herbal formulation showed high activity with IC₅₀ 48–48.89 µg/mL and reduced Bcl-2 expression at ≥60 µg/mL. In conclusion, natural products are promising anticancer candidates, but further selectivity, in vivo, and clinical validation are required.

Keywords

anticancer, natural products, IC50, apoptosis, MCF-7, in silico

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