Vol. 21 No. 4 (2025)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

COMPARISON OF KNOWLEDGE AND THERAPEUTIC OUTCOME USAGE ON DIABETES MELLITUS BETWEEN METFORMIN AND GLIMEPIRIDE: A SYSTEMATIC LITERATURE REVIEW 2020-2025

Published 2025-12-30

  • Yuni Kristina Purba
    • ,
  • Sylvia Rizky Prima

Yuni Kristina Purba
Universitas 17 Agustus 1945 Jakarta

Sylvia Rizky Prima
Universitas 17 Agustus 1945 Jakarta

Abstract

Diabetes mellitus merupakan masalah kesehatan global dengan angka kejadian yang terus meningkat, sehingga memerlukan pengelolaan yang tepat dan edukasi pasien mengenai terapi yang dijalankan. Metformin dan glimepiride merupakan dua jenis obat antidiabetik oral yang sering digunakan, namun efektivitas dan hasil terapi dapat dipengaruhi oleh tingkat pengetahuan pasien. Studi ini bertujuan untuk membandingkan tingkat pengetahuan pasien serta therapeutic outcome pada penderita diabetes mellitus yang menggunakan metformin dan glimepiride. Metode penelitian observasional dilakukan pada pasien Diabetes mellitus dengan evaluasi pengetahuan terkait penggunaan obat serta hasil terapi yang diukur melalui penurunan kadar gula darah. Hasil menunjukkan baik metformin maupun glimepiride memberikan penurunan kadar gula darah yang efektif, yaitu rata-rata sebesar 33,61 mg/dL pada metformin dan 31,51 mg/dL pada glimepiride, tanpa perbedaan signifikan secara statistik antar kedua kelompok (p>0,05). Tingkat pengetahuan pasien turut berperan dalam pencapaian outcome terapi, namun tidak ditemukan perbedaan bermakna antara kelompok metformin dan glimepiride. Kesimpulan dari penelitian ini adalah efektivitas terapi dan tingkat pengetahuan pasien dalam penggunaan metformin maupun glimepiride relatif serupa. Edukasi berkelanjutan tetap penting untuk mendukung keberhasilan pengelolaan diabetes mellitus. 

Keywords

Diabetes Mellitus, Metformin, Glimepiride, Perbandingan Metformin dan Glimepiride, Pengetahuan Pasien Diabetes, Therapeutic Outcome Diabetes, Edukasi Pengobatan Diabetes, Evaluasi Terapi Diabetes

pdf

References

  1. Abd Al-Aziz, M. F., Manal, M., Shady, A., & Abd El-Hamid, S. (2018). Safety and efficacy of fixed dose combination of glimepiride and metformin in type 2 diabetic patients in Egypt: A real-life study. The Medical Journal of Cairo University, *86*(9), 2599–2603. https://doi.org/10.21608/MJCU.2018.58063
  2. Abrahamson, M. J., & Peters, A. (2012). Intensification of insulin therapy in patients with type 2 diabetes mellitus: An algorithm for basal-bolus therapy. Journal of Joslin Diabetes Center, *44*(1), 836–846.
  3. Artini, T. L., & Saifana, C. A. (2022). Gambaran penggunaan antidiabetes oral pada pasien diabetes mellitus tipe 2. Prosiding Seminar Informasi Kesehatan Nasional.
  4. Balkhi, B., Alwhaibi, M., Alqahtani, N., Alhawassi, T., Alshammari, T. M., Mahmoud, M., Almetwazi, M., Ata, S., & Kamal, K. M. (2019). Oral antidiabetic medication adherence and glycaemic control among patients with type 2 diabetes mellitus: A cross-sectional retrospective study in a tertiary hospital in Saudi Arabia. BMJ Open, *9*(7), e029280. https://doi.org/10.1136/bmjopen-2019-029280
  5. Chaudhury, A., Duvoor, C., Reddy Dendi, V. S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., Patil, N., Musham, C. K., Lohani, G. P., & Mirza, W. (2017). Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Frontiers in Endocrinology, *8*, 6. https://doi.org/10.3389/fendo.2017.00006
  6. DiNicolantonio, J. J., Bhutani, J., & O’Keefe, J. H. (2015). Acarbose: Safe and effective for lowering postprandial hyperglycaemia and improving cardiovascular outcomes. Open Heart, *2*(1), e000327. https://doi.org/10.1136/openhrt-2015-000327
  7. Elvaretta, R., & Sudarsono. (2021). Kajian efek samping gangguan fungsi ginjal penggunaan glimepiride pada penyakit diabetes mellitus tipe 2 di Rumah Sakit Anwar Medika [Tesis magister, Universitas Stikes RS Anwar Medika].
  8. Fatimah, R. N. (2015). Diabetes melitus tipe 2. Jurnal Majority, *4*(5), 93–99.
  9. Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. International Journal of Molecular Sciences, *21*(17), 6275. https://doi.org/10.3390/ijms21176275
  10. Gottschalk, M., Danne, T., Vlajnic, A., & Cara, J. F. (2007). Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: A randomized, single-blind comparative study. Diabetes Care, *30*(4), 790–794. https://doi.org/10.2337/dc06-1504
  11. Health Organization. (2024). SDGs sustainable development goals. http://apps.who.int/bookorders
  12. Hermann, L. S., Scherstén, B., Bitzen, P. O., Kjellström, T., Lindgärde, F., & Melander, A. (1994). Therapeutic comparison of metformin and sulfonylurea, alone and in various combinations: A double-blind controlled study. Diabetes Care, *17*(10), 1100–1109. https://doi.org/10.2337/diacare.17.10.1100
  13. Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008). 10-year follow-up of intensive glucose control in type 2 diabetes. The New England Journal of Medicine, *359*(15), 1577–1589. https://doi.org/10.1056/NEJMoa0806470
  14. Korean Diabetes Association. (2011). Treatment guideline for diabetes. http://www.diabetes.or.kr/pro/publish/sub04.php?mode=list
  15. Li, T., Quan, H., Zhang, H., Lin, L., Lin, L., Ou, Q., & Chen, K. (2021). Type 2 diabetes is more predictable in women than men by multiple anthropometric and biochemical measures. Scientific Reports, *11*(1), 6062. https://doi.org/10.1038/s41598-021-85581-z
  16. Mohammed, S. I., Chopda, M. Z., Patil, R. H., Vishwakarma, K. S., & Maheshwari, V. L. (2016). In vivo antidiabetic and antioxidant activities of Coccinia grandis leaf extract against streptozotocin induced diabetes in experimental rats. Asian Pacific Journal of Tropical Disease, *6*(4), 298–304. https://doi.org/10.1016/S2222-1808(15)61039-7
  17. Perkeni. (2019). Pedoman pengelolaan dan pencegahan DM tipe 2 dewasa Indonesia. Perkumpulan Endokrinologi Indonesia. https://pbperkeni.or.id/wp-content/uploads/2020/07/Pedoman-Pengelolaan-DM-Tipe-2-Dewasa-di-Indonesia-eBook-PDF-1.pdf
  18. Pignatello, R. (Ed.). (2013). Drug-biomembrane interaction studies: The application of calorimetric techniques. Woodhead Publishing Limited. https://doi.org/10.1533/9781908818348.1
  19. Qian, D., Zhang, T., Tan, X., Zheng, P., Liang, Z., Xie, J., Jiang, J., & Situ, B. (2018). Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis. PLOS ONE, *13*(8), e0202563. https://doi.org/10.1371/journal.pone.0202563
  20. Rasmussen, J., Nordin, L., Rasmussen, N., Thomsen, J., Street, L., Bygbjerg, I., & Christensen, D. (2014). Random blood glucose may be used to assess long-term glycaemic control among patients with type 2 diabetes mellitus in a rural African clinical setting. Tropical Medicine & International Health, *19*(12), 1515–1519. https://doi.org/10.1111/tmi.12391
  21. Riset Kesehatan Dasar. (2018). Hasil utama RISKESDAS 2018. Kementerian Kesehatan Republik Indonesia.
  22. Rodríguez-Almagro, J., García-Manzanares, Á., Lucendo, A. J., & Hernández-Martínez, A. (2018). Health-related quality of life in diabetes mellitus and its social, demographic and clinical determinants: A nationwide cross-sectional survey. Journal of Clinical Nursing, *27*(21-22), 4212–4223. https://doi.org/10.1111/jocn.14624
  23. Sheik Abdulazeez, S. (2015). Diabetes treatment: A rapid review of the current and future scope of stem cell research. Saudi Pharmaceutical Journal, *23*(4), 333–340. https://doi.org/10.1016/j.jsps.2013.12.010
  24. Skyler, J. S., Bergenstal, R., Bonow, R. O., Buse, J. B., Deedwania, P., Gale, E. A. M., Howard, B. V., Kirkman, M. S., Kosiborod, M., Reaven, P., & Sherwin, R. S. (2009). Intensive glycemic control and the prevention of cardiovascular events: Implications of the ACCORD, ADVANCE, and VA diabetes trials: A position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care, *32*(1), 187–192. https://doi.org/10.2337/dc09-9026
  25. Wu, H., Patterson, C. C., Zhang, X., Ghani, R. B. A., Magliano, D. J., Boyko, E. J., Ogle, G. D., & Luk, A. O. Y. (2022). Worldwide estimates of incidence of type 2 diabetes in children and adolescents in 2021. Diabetes Research and Clinical Practice, *185*, 109785. https://doi.org/10.1016/j.diabres.2022.109785
  26. Zhao, Y., Xu, G., Wu, W., & Yi, X. (2015). Type 2 diabetes mellitus-disease, diagnosis and treatment. Journal of Diabetes & Metabolism, *6*(5), 1000533. https://doi.org/10.4172/2155-6156.1000533
  27. Zhu, H., Zhu, S., Zhang, X., Guo, Y., & Shi, Y. (2013). Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: Meta-analysis of randomized controlled trials. Hunan Journal of Traditional Chinese Medicine, *29*(7), 154–156.

Similar Articles

21-30 of 368

You may also start an advanced similarity search for this article.