Vol. 21 No. 3 (2025)
Medic Nutricia : Jurnal Ilmu Kesehatan, ISSN : 3025-8855

Articles

UJI AKTIVITAS HEPATOPROTEKTOR EKSTRAK DAUN UBI JALAR PUTIH (Ipomoea batatas Lamk.) TERHADAP KADAR SGOT DAN SGPT PADA TIKUS PUTIH JANTAN YANG DIINDUKSI PARASETAMOL

Published 2025-11-04

  • Dinda Syahfudtri
    • ,
  • Erni Rustiani
    • ,
  • Dewi Oktavia

Dinda Syahfudtri
Universitas Pakuan Bogor

Erni Rustiani
Universitas Pakuan Bogor

Dewi Oktavia
Universitas Pakuan Bogor

Abstract

The liver is a vital organ that functions in metabolism, detoxification, and protein synthesis. Liver damage can lead to various health problems such as chronic liver disease and liver failure, which may be caused by drugs such as paracetamol. Efforts to prevent liver damage can be managed through the use of hepatoprotective agents. Hepatoprotectors are compounds that protect liver cells and repair damaged liver tissues caused by toxic substances. This study aimed to determine the effect of white sweet potato (Ipomoea batatas) leaf extract and to identify the most effective dose in reducing SGOT and SGPT levels in male white rats induced with paracetamol. The method used in this study was the hepatoprotective activity assay, with test parameters including measurements of SGOT and SGPT levels in male white rats induced with paracetamol for 24 hours. The experimental design consisted of five groups: normal control, negative control, positive control I (Urdafalk 16.67 mg/200 g BW), positive control II (Hepamax 46.9), and two treatment groups with white sweet potato leaf extract—dose I (80 mg/kg BW) and dose II (160 mg/kg BW). The results showed that both dose I and dose II of white sweet potato leaf extract were able to reduce SGPT and SGOT levels in paracetamol-induced male white rats. The most effective dose was dose II (160 mg/200 g BW), which resulted in a 66.872% decrease in SGPT levels and a 47.218% decrease in SGOT levels. Both doses of white sweet potato leaf extract demonstrated hepatoprotective activity, supported by improvements in liver, heart, kidney, and spleen organ indices as additional parameters

Keywords

Keywords: White Sweet Potato Leaves, Hepatoprotector, Paracetamol, Male White Rats

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References

  1. Abdulkadir, F. ., Musthapa, M., & Haruna, H. M. . (2017). Phytochemical Screening and in vitro Activity of Allium cepa. L. Ethanol Extract Against Bacteria Isolated from Hawked Moringa oleifera Meal Sold within Kaduna Metropolis. Dalam Ladeska. V., Rindita, Amyra. N., & Veranthy. T. D., Analisa Fisikokimia dan A. Jurnal Jamu Indonesia, 5, 56–67.
  2. Abidin, Z. Z., & Mardiyantoro, F. (2020). Diagnosis dan tata laksana perdarahan rongga mulut. Universitas Brawijaya Press.
  3. Acute Liver Failure Study Group. (2017). Etiology of Acute Liver Failure in the USA Adult Registry.
  4. Andini, M., Sani, F. K., & Rahman, H. (2022). Uji Hepatoprotektor Ekstrak Etanol Daun Ekor Naga (Epipremnum pinnatum (L.) Engl.) Terhadap Mencit Putih Jantan Yang Diinduksi Paracetamol. Indonesian Journal of Pharma Science, 4(1), 104–112.
  5. Arziyah, D., Yusmita, L., & Wijayanti, R. (2022). Analisis Mutu Organoleptik Sirup Kayu Manis Dengan Modifikasi Perbandingan Konsentrasi Gula Aren Dan Gula Pasir. Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta, 1(2), 105–109.
  6. Baek, H. J., Lee, Y. M., Kim, T. H., Kim, J. Y., Park, E. J., Iwabuchi, K., Mishra, L., & Kim, S. S. (2016). Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage. International Journal of Biological Sciences, 12(2), 172–183.
  7. Bhakuni, G. S., Bedi, O., Bariwal, J., Deshmukh, R., & Kumar, P. (2016). Animal Models of Hepatotoxicity. Inflammation Research, 65(1), 13–24.
  8. DepKes RI. (2020). Farmakope Indonesia Edisi VI. Kementrian Kesehatan Republik Indonesia.
  9. DepKes RI. (2022). Formalium Herbal Suolemen Edisi II. Departemen Kesehatan Republik Indonesia.
  10. Elkomy, A., Aboubakr, M., Soliman, A., Abdeen, A., Abdelkader, A., & Hekal, H. (2016). Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats. International Journal of Pharmacology and Toxicology, 4(2), 187–190.
  11. Gultom, A. M. K., Yusa, N. M., & Wiadnyani, A. A. I. S. (2020). Pengaruh jenis pelarut terhadap aktivitas antioksidan ekstrak daun ubi jalar putih (Ipomoea batatas L) menggunakan metode maserasi. Jurnal Ilmu Dan Teknologi Pangan (ITEPA), 9(4), 438–447.
  12. Hanani, E. (2015). Analisis Fitokimia. EGC.
  13. Jasat, H., Thompson, J. P., Sonneborn, O., Dayment, J., & Miller, C. (2021). Prolonged use of paracetamol and the prescribing patterns on rehabilitation facilities. Journal of Clinical Nursing, 31(23–24), 3605-3616. https://doi.org/10.1111/jocn.16188
  14. KemenKes RI. (2017). Formalium Ramuan Obat Tradisional Indonesia. Kementerian Kesehatan Republik Indonesia.
  15. Masola, A. B. C. P., Panda, A. L., & Kawengian, V. (2016). Hubungan gagal jantung dan gangguan fungsi hati. Jurnal E-Clinic (ECl), 4(2), 1–5.
  16. Maulina, S. (2018). Fungsi hati dan mekanisme metabolisme empedu. Jurnal Biologi Sel Dan Jaringan, 13(2), 102–115.
  17. Nofita., Ulfa, A. M., & Muslim, D. M. (2020). Analisis Sgot Dan Sgpt Pada Tikus Jantan Yang Di Induksi Parasetamol Untuk Menetapkan Aktivitas Ekstrak Buah Delima (Punica Granatum L.) Sebagai Hepatoprotektif. Jurnal Malahayati, 3(1), 12–21.
  18. Nursidika, P. (2017). Gambaran abnormal organ hati dan ginjal Pasien Tuberkulosis Yang Mendapatkan Pengobatan. Jurnal Kesehatan Kartika, 12(1), 1–11.
  19. Qodriyati, N. L. Y., Sulistyani, E., & Yuwono, B. (2016). Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) padaTikus Wistar (Rattus norvegicus) Jantan yang Dipapar StresorRasa Sakit Electrical Foot Shock selama 28 Hari(The Level of Serum Glutamic Oxaloacetic Transaminase (SGOT)in Male Wistar Rat (Rattus norv. E-Jurnal Pustaka Kesehatan, 4(1), 73–77.
  20. Ramadhan, A., Lubis, Y. M., Nasution, S. W., Nasution, S. L. R., Girsang, E., & Nasution, A. N. (2019). Uji Efektivitas Ekstrak Buah Kurma (Phoenix dactylifera) Dan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Sebagai Nefroprotektor Terhadap Tikus Yang DiInduksi Parasetamol. Jurnal Farmacia, 1(1), 8–15.
  21. Rasyid, S. A., Armayani., Yuniati., & Lio, T. M. P. (202 C.E.). Analysis of Serum Glutamic Pyruvic Transaminase and Serum Glutamic Oxaloacetic Transaminase Levels In Tuberculosis Patients Who Are Undergoing Oat Treatment In Kendari City General Hospital, Kota Kendari, Indonesia. Infectious Disease Report, 12, 75-77.
  22. Sugiharto, W., & Martini, T. (2018). Pengaruh pemberian ekstrak umbi bawang dayak (Eleutherine palmifolia L. Merr.) terhadap kadar MDA (Malondialdehid) serum tikus putih (Rattus norvegicus) jantan galur Wistar yang diinduksi parasetamol. Skripsi. Fakultas Kedokteran Universitas Hang Tuah Surabaya.
  23. Sun, H., Mu, T., Xi, L., Zhang, M., & Chen, J. (2014). Sweet Potato (Ipomoea Batatas L) Leaves as Nutritional and Functional Foods. J. Food Chemistry, 156, 380–389.
  24. Suwantara, J. (2016). Pengaruh Ekstrak Etanol Daun Ubi Jalar (Ipomoea batatas LAMK.) Sebagai Hepatoprotektor. 2(2).
  25. Wahyuningtyas, P., Sitasiwi, A. J., & Mardiati, M. S. (2018). Hepatosomatic Index (Hsi) Dan Diameter Hepatosit Mencit (Mus musculus L.) Setelah Paparan Ekstrak Air Biji Pepaya (Carica papaya L.). Jurnal Akademika Biologi., 7(1), 8–17.
  26. Wintari, N. I., & Suena, N. M. D. S. (2017). pengaruh ekstrak etanol daun ubi jalar (Ipomoea batatas lAMK) sebagai hepatoprotektor terhadap kadar bilirubin total pada tikus putih jantan galur wistar. Jurnal Ilmiah Medicamento, 3(2), 110–114.

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